Zenit St Petersburg striker Hulk will miss Tuesday's Champions League match at Anderlecht because of a thigh injury.
The Brazil international, who was injured in Friday's league game against Rostov, will be sidelined for up to two weeks, the Russian champions said on their website.
Hulk's injury is a major blow to Luciano Spalletti's team, who are third in Group C with three points, two points above Anderlecht after beating the Belgian champions 1-0 last month in St Petersburg.
The powerful forward has been Zenit's top scorer since joining them for a Russian league record 60 million euros just before the transfer deadline.
Hulk will also miss Brazil's friendly against Colombia in the United States next Wednesday.
Berlin will stage Champions League final for the first time in 2015
Borussia Dortmund's Mario Gotze ruled out of Champions League final against Bayern Munich
Manchester United centre-back Rio Ferdinand signs one-year contract
Malaga coach Manuel Pellegrini will leave the La Liga club at the end of the current season
Ten years on, the legends speak to FFT
Your questions answered by an A to Z of legends
He's here, he's there, he's...
The cost of Premier League away travel
Nike CR7 IX for you
FourFourTwo is brought to you by Haymarket Consumer Media & FourFourTwo is part of Haymarket Sport
| International Licensing | © Haymarket Media Group 2010