Inter Milan's main striker Diego Milito is likely to miss the rest of the season after suffering a cruciate knee ligament injury during Thursday's 2-0 Europa League win over CFR Cluj.
The Argentine, who scored both goals in the final when Inter won the Champions League in 2010, had only just returned from injury and was in tears when he was carried off after six minutes at the San Siro.
"It's his cruciate ligament, a new type of injury for Diego, nothing to do with the problems he's had before," coach Andrea Stramaccioni told reporters.
"We're gutted for Diego as a person first and foremost, and then of course for what he represents as a player. We need to see when he'll have the operation."
Compatriot Rodrigo Palacio replaced Milito and scored both goals in the first leg of the round of 32 tie but he is generally a winger.
Inter, fourth in Serie A, must now face the final three months of the season without their only real out-and-out striker.
Real Madrid and Jose Mourinho will part company at the end of the current season
Manchester City midfielder called up to the England squad for summer friendlies
Spurs miss out on Champions League again despite highest Premier League points tally
Champions closer to matching Real Madrid's La Liga record of 100 points with 2-1 win
Ten years on, the legends speak to FFT
Your questions answered by an A to Z of legends
He's here, he's there, he's...
The cost of Premier League away travel
Nike CR7 IX for you
FourFourTwo is brought to you by Haymarket Consumer Media & FourFourTwo is part of Haymarket Sport
| International Licensing | © Haymarket Media Group 2010