Rodrigo Palacio scored twice as Inter Milan cruised through to the Europa League knockout stages on Thursday while holders Atletico Madrid's 16-match unbeaten run came to an end in Portugal.
Inter, who beat Partizan Belgrade 3-1 in Serbia with all the goals coming in the second half, were joined in the next phase by Bayer Leverkusen, Rubin Kazan, Metalist Kharkiv, Hannover 96 and Olympique Lyon.
Russian side Kazan moved to the top of Group H, level on 10 points with Inter, after a 1-0 win at Azerbaijan's Neftchi Baku thanks to Vladimir Dyadyun's 16th minute strike.
Leverkusen and Metalist were also level on 10 points in Group K, the Germans too good for Rapid Vienna with a 3-0 home win while their Ukrainian rivals beat Norway's Rosenborg 3-1.
Palacio's double for Inter and a third from Fredy Guarin late on saw off Partizan, who netted a consolation goal in injury time through Nemanja Tomic.
Jens Hegeler's fourth-minute strike got Leverkusen off to the perfect start and goals after the break from Andre Schuerrle then Manuel Friedrich settled the outcome.
Hannover's last-gasp win came courtesy of an injury-time Szabolcs Huszti penalty that took the Germans to 10 points in Group L. Levante held Twente Enschede 0-0 in the same group and are on seven points.
Lyon maintained their perfect record with a 3-2 win at last year's finalists Athletic Bilbao to streak ahead of Group I rivals Sparta Prague, still in second after a 1-1 draw away to Israel's Hapoel Ironi Kiryat Shmona.
Wilson Eduardo netted twice for Academica against Atletico Madrid to keep alive their slim hopes of reaching the last 32 with a 2-0 win.
Czech side Viktoria Plzen took advantage of Atletico's slip-up and joined them at the top of Group B after easing to a 4-0 home win against Hapoel Tel Aviv.
Plzen and Atletico have nine points each while Academica are on four with two rounds of matches remaining in the 48-team group stage of the competition.
Treble UEFA Cup winners Liverpool suffered a setback in Moscow after they were beaten 1-0 by Anzhi Makhachkala, who went top of Group A when Ivorian Lacina Traore scored a superb winner on the stroke of half-time.
With one eye on Sunday's Premier League clash at Chelsea, Liverpool manager Brendan Rodgers fielded a makeshift side who were undone by the lanky 22-year old striker.
Traore took a long through ball into his stride and left two Liverpool defenders flat-footed with a cheeky turn before he dispatched a perfect lob over goalkeeper Brad Jones from the edge of the penalty box.
The result left Liverpool second in Group A, a point behind Anzhi on seven but level with Young Boys who were surprise 3-2 winners at Udinese. Italian striker Antonio Di Natale missed a penalty for the home side before scoring an equaliser.
Udinese are three points adrift of Anzhi.
Newcastle United held Club Bruges to a 2-2 draw in Group D after coming back from two goals down.
Napoli's Edinson Cavani scored four goals as the Italians twice came from behind to beat Ukraine's Dnipro Dnipropetrovsk 4-2 at home and stay in the hunt to progress from Group F.
In Group E Steaua Bucharest moved closer to qualification with a 2-1 win away to Norway's Molde for a lead of five points over VfB Stuttgart, who beat Copenhagen 2-0 in Denmark.
Olympique Marseille and Borussia Monchengladbach continued their dogfight with a 2-2 draw on the French coast in Group C.
They both have five points and are as many behind Fenerbahce after the Turkish champions beat Cypriots AEL Limassol 2-0 in Istanbul.
Swedish club AIK beat PSV Eindhoven in Stockholm thanks to a first-half wonder goal from on-loan Celtic striker Mohamed Bangura.
"If you're going to win these games, you have to score great goals. Mohamed scored a fantastic goal. A brilliant achievement," AIK coach Andreas Alm told Sweden's TV4 Sport.
Italy's Lazio beat Greece's Panathinaikos 3-0 to take a two-point lead over Tottenham Hotspur in Group J.
Spurs beat Maribor 3-1 in emotional scenes as Fabrice Muamba returned as a spectator to the White Hart Lane ground where he almost died in March.
Bayern overcome heartbreak of losing two finals in three seasons by beating Dortmund 2-1
Decision not to send off Bayern Munich defender Dante rankles with upbeat Dortmund boss
Heynckes becomes only the fourth manager to win the European Cup with two different teams
Dortmund striker could soon join German rivals and newly-crowned Champions League winners
Ten years on, the legends speak to FFT
Your questions answered by an A to Z of legends
75% of all TV is Bale
On the road to ruin
Nike CR7 IX for you
FourFourTwo is brought to you by Haymarket Consumer Media & FourFourTwo is part of Haymarket Sport
| International Licensing | © Haymarket Media Group 2010