Bordeaux, who had gone three league matches without a win, suggested their lean spell was over, four days after knocking out Greek side Olympiakos to reach the quarter-finals of the Champions League, where they will face Olympique Lyon.
The team from the wine capital, who have a game in hand, top the standings on goal difference from surprise package Montpellier, 2-1 winners over Valenciennes.
Auxerre, who beat Le Mans 2-1 on Saturday, are in third, a point back, while Olympique Marseille moved up to fourth, two further points adrift, with a 2-1 home win over Olympique Lyon in late action on Sunday.
Defender Taye Taiwo gave Marseille the points with a powerful angled shot eight minutes from time, dealing a severe blow to Lyon's title chances, with the seven-times champions now five points off the pace in sixth place.
Midfielder Charles Kabore put Marseille ahead with a deflected shot from the edge of the box on 67 minutes but substitute striker Bafetimbi Gomis then put Lyon level with a headed goal from a free-kick.
Bordeaux coach Laurent Blanc was not totally satisfied with his team's performance and called for improvement in their next games, starting with next Saturday's French League Cup final against Olympique Marseille.
"We struggled for the first 20 minutes and allowed Lille to open the scoring with a defensive blunder," he said. "We didn't play great and we need to play better in our next matches."
The turning point came on 65 minutes when Lille defender Ricardo Costa was red-carded for a challenge in the box on Morocco striker Marouane Chamakh.
Brazilian forward Jussie converted the resulting penalty to give the home side a 2-1 lead. Playmaker Yoann Gourcuff then wrapped it up from close range to put Bordeaux on 56 points from 28 games.
Belgian winger Eden Hazard had sprinted through the Bordeaux defence to put Lille ahead on 24 minutes. Defender Michael Ciani volleyed home to put Bordeaux level 15 minutes later.
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