Wojciech Szczesny makes his Champions League debut for Juventus against Olympiacos after Gianluigi Buffon failed to recover from a calf injury in time to play in the pivotal Group D clash.
The absence of veteran goalkeeper Buffon is a blow for the Italian side, particularly as they are also without defender Giorgio Chiellini for the game in Greece.
However, Miralem Pjanic - who was doubtful due to a muscle strain - is fit enough to take a seat on Juve's bench.
Szczesny has yet to feature in Europe this season but has played five times in Serie A, with his most recent appearance coming in the 3-2 loss to Sampdoria on November 19.
Head coach Massimiliano Allegri is able to name Mario Mandzukic as a substitute, with the forward back again after missing last Friday's 1-0 win away at Napoli.
Gonzalo Higuain starts up front as Juve look to secure a victory over the Greek champions that will see them qualify for the knockout stages of the competition.
Anything but a win, though, and Sporting CP - who travel to Camp Nou to face Barcelona - could climb above them to take second place.
Juventus XI: Szczesny; De Sciglio, Barzagli, Benatia, Alex Sandro; Khedira, Matuidi; Cuadrado, Dybala, Douglas Costa; HiguainSubs: Pinsoglio, Rugani, Asamoah, Pjanic, Marchisio, Bernardeschi, MandzukicDecember 5, 2017
Alexia Putellas: "We’re already the only club to have won the men’s and women’s Champions League, so the only thing even more historic to do than that would be to win it in the same season"
‘Trent has won everything he can for Liverpool, but of those who’ve left that we wanted to stay, who’s actually done better? I can only come up with one’: Reds legend highlights potential danger of Alexander-Arnold moving to Real Madrid
