If Manchester City beat Stoke in a replay on February 24, the cup meeting could bring together former Chelsea team mates John Terry and Wayne Bridge, who have fallen out over personal matters, face to face for the second week in succession.
Chelsea are due to host Manchester City in a Premier League match on February 27 when left back Bridge is expected to return to Stamford Bridge for the first time since media allegations that Terry had an extra-marital affair with Bridge's former girlfriend.
With four of this weekend's fifth-round ties ending in draws, the only definite pairing will see debt-ravaged Portsmouth facing Birmingham City at Fratton Park when the quarter-final ties are played on the weekend of March 6 and 7.
Fulham, who saw off League Two Notts County on Sunday, host the winners of the replay between Bolton Wanderers and Tottenham Hotspur.
If Championship side Crystal Palace beat Premier League Aston Villa in their replay at Villa Park they will face the winners of the all-Championship replay between Reading and West Bromwich Albion.
Full draw:
Chelsea v Manchester City or Stoke City
Fulham v Bolton Wanderers or Tottenham Hotspur
Reading or West Bromwich Albion v Crystal Palace or Aston Villa
Portsmouth v Birmingham City
