His absence will be a major loss to manager Mark Hughes' plans, with Kompany having impressed following his arrival from Hamburg last August.
The Blues' midfield was already depleted with another Dutchman and former Hamburg star, Nigel de Jong, ineligible to play in the competition, while Irish international Stephen Ireland is also a doubt, despite travelling with the squad.
However, better news for City is that Bulgarian winger, Martin Petrov, is fit having recovered from a lengthy injury sustained last summer. The midfielder returned to action for the club's reserves on Monday.
Hughes’ side will be hoping to continue a decent run of results away from home in Europe, compared to their drastic Premier League form on the road where they have triumphed on just one occasion this season, away at Sunderland in August.
However, in the UEFA Cup, City have won away at EB Streymur, Midtjylland, Omonia Nicosia and Schalke, losing to Racing Santander and Aalborg and drawing in Copenhagen.
They travel to an in-form Hamburg side, who currently sit second in the Bundesliga and have lost only once at home in the league in 13 outings this season.
CITY FANS! Check FourFourTwo.com’s ever-expandinginterviews archivefor more stuff to read:
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