The 44-year-old spent a season in the Celta hot seat before assuming the Barca reins during the close-season and will be keen for a return to winning ways following a 3-1 defeat to Real Madrid last time out.
Barca remain at the Liga summit despite that loss, but Luis Enrique believes a victory over his former employers will be far from straightforward.
"It is the most special game to prepare for," he said. "I've found it even stranger because I know many of the Celta players.
"I think they are a very dangerous outfit. I'm so glad they are having a great start to the season.
"I have many memories of my time at the Galician club. It is a great club with great values."
Celta currently sit sixth in the Spanish top flight having lost just one match so far this season.
