The Red Devils, trailing 2-1 from the first leg tie in the Italian capital, returned to the Theatre of Dreams and blew Luciano Spalletti's side away in April 2007, with Michael Carrick, Alan Smith, Wayne Rooney and Cristiano Ronaldo all netting before the break, before Ronaldo, Carrick and Patrice Evra added further strikes in the second half.
And despite the Scot enjoying countless famous nights in Europe, including United's two title-winning triumphs against Bayern Munich in 1999 and Chelsea in 2008, Ferguson insists his side's record-breaking hammering of Roma usurps them all.
"Without a doubt, the 7-1 victory over AS Roma at Old Trafford was the best," he said in the May issue of The Technician, UEFA's newsletter for coaches.
"It was a record score for the Champions League. We went into that game against a top Italian side that had beaten us 2-1 in the first leg.
"Our first-half performance was out of this world, and Luciano Spalletti's team were shell-shocked because our quick, one-touch play was exceptionally good.
"Some of our goals were brilliant, in particular the fluid, one-touch play leading to the strike by Alan Smith. That game certainly stands out. As does the 3-3 draw away to Barcelona [in November 1998] which could have ended up 20-20 the way both teams attacked."
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