Bayern played more than 70 minutes with 10 men on Tuesday in a last-gasp 3-2 defeat at Premier League champions Manchester City.
Defender Mehdi Benatia was sent off in the 20th minute of the UEFA Champions League loss but Bayern - missing injured pair Philipp Lahm and David Alaba, and with Thomas Muller and Mario Gotze on the bench - were still able to overturn a 1-0 deficit.
Bayern had already qualified for the last 16 in Europe's premier club competition so the defeat ultimately meant little, but it did signal their first loss since August.
Pep Guardiola's men are sure to be keen to avenge that but will face a fresher Hertha side who had no midweek commitments.
However, goalkeeper Manuel Neuer has admitted Bayern's players are suffering from fatigue after their defeat in England.
"We were drained of energy," Neuer told Bayern's official website. "But that's normal when you play for so long with ten men."
Defender Rafinha echoed his team-mate's thoughts and added: "Playing for so long with a man less is very hard work."
Recovering from a knee injury, Schweinsteiger has appeared off the bench in Bayern's last two matches.
Germany's World Cup hero is the joint top-scorer in Bundesliga with seven this season.
While Bayern have won seven of their last eight league matches, Hertha's form is more patchy.
Defender Marcel N'Djeng scored an 86th-minute winner on that occasion, his first goal in more than 18 months.
Three of Hertha's four Bundesliga wins have come at home and a 1-0 triumph over second-placed Wolfsburg in September was impressive.
But despite that, and Bayern's fatigue, they will have their work cut out to gain victory on Saturday.
