Iniesta was jeered by sections of the Amsterdam Arena support during the friendly win, with Stefan de Vrij and Davy Klaassen scoring to ease the pressure on under-fire boss Hiddink.
However, the 68-year-old was unhappy with the reception given to Iniesta - who scored the winning goal in the 2010 World Cup final between the sides.
"It's a disgrace. If such a world-class player is booed you should be ashamed deeply as the public," he told reporters.
"I asked the bench why they did that, I did not understand. Iniesta is firstly a fantastic footballer and also a great person.
"I found this reaction very inappropriate and shameless."
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