Juventus will be without Gonzalo Higuain and Medhi Benatia for their Champions League trip to Sevilla.
Argentina striker Higuain completed 90 minutes in Saturday's 3-0 Serie A win over Pescara but picked up an injury to his left thigh.
Centre-back Benatia did not feature at the weekend and has a knee problem.
Neither player has travelled with Massimiliano Allegri's squad for Tuesday's Group H match, where victory at the Ramon Sanchez Pizjuan would guarantee Juve's progress to the last 16.
Our squad list is in.Medical updates on and November 21, 2016
A statement on Juventus' official website read: "Gonzalo Higuain will not be on the plane to Spain after sustaining bruising to his left thigh in the final minutes of Saturday’s win over Pescara.
"The forward’s condition will be monitored closely over the coming days. Medhi Benatia, meanwhile, has not yet fully recovered from a knock to his right knee."
With Paulo Dybala still sidelined, Higuain's absence means Mario Mandzukic and 16-year-old Moise Kean are the only recognised strikers in the travelling party.
Kean would become the first player born this millennium to feature in the Champions League if he plays a part, having secured the same distinction in Serie A against Pescara.
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