Long started in their 3-0 defeat to Arsenal on Sunday but was substituted at half-time and replaced by Matty Fryatt, having wasted a handful of opportunities in the opening half.
Aluko was not involved in the matchday squad, having expressed his dissatisfaction at being benched in recent weeks, and Bruce is beginning to grow concerned at the forward's mounting injury problems.
“He's (Long) got a calf injury, we'll see how he is, he'll be touch and go for the weekend," Bruce said after Sunday's defeat.
“Sone Aluko nicked a hamstring on Thursday, unfortunately it's becoming too often (that he gets injured).
"We get him up to speed and he breaks down again, it's a huge disappointment and a concern.
"It's not serious but could be 10-12 days (before he's back); he's 50-50 for next week."
Victory over Fulham at Craven Cottage could secure Hull's place in the top flight for next season, they currently sit six points above the bottom three with four games remaining.
