Tottenham are likely to be without Harry Kane as they begin life after Jose Mourinho against Southampton.
The England captain suffered an ankle injury in Mourinho’s last game in charge at Everton and has not trained since, so interim head coach Ryan Mason is set to be without him.
Matt Doherty (muscle) is back in contention but Ben Davies (ankle) is still out.
Southampton can welcome back on-loan Liverpool winger Takumi Minamino, who was cup-tied for Sunday’s FA Cup semi-final defeat by Leicester.
Striker Michael Obafemi has returned to training following the muscle injury which has ruled him out since January, but he is short of match fitness.
Oriol Romeu (ankle) and William Smallbone (knee) remain long-term absentees.
Tottenham provisional squad: Lloris, Hart, Aurier, Doherty, Tanganga, Dier, Alderweireld, Rodon, Sanchez, Reguilon, Hojbjerg, Winks, Sissoko, Ndombele, Alli, Lamela, Moura, Kane, Vinicius, Bale, Son.
Southampton provisional squad: Forster, Walker-Peters, Bertrand, Vestergaard, Bednarek, Ward-Prowse, Redmond, Armstrong, Diallo, Ings, Walcott, McCarthy, Stephens, Salisu, Djenepo, Minamino, Jankewitz, Adams, Tella, Ferry.
Bizarre Jose Mourinho statement aims to pre-empt punishment after Fenerbahce boss clashes with Galatasaray counterpart
'Andy Robertson has a decision to make as a player, where you either roll your sleeves up and give someone great competition or you accept decisions and say that your time is done.' Alan Shearer on the conundrum facing Arne Slot's Liverpool
