Elie Baup was sacked as Marseille coach after their loss to Nantes on Friday and sporting director Jose Anigo has been named caretaker boss.
Fifth in Ligue 1, Marseille face a side sitting just two places below them on the table in the Coupe de France.
Fourth-placed Nantes meet top-flight battlers Nice and Bastia will face Evian TG in other ties.
The only other all-Ligue 1 battle is between Rennes and relegation-battling Valenciennes, who are five points from safety.
Ligue 1 leaders Paris Saint-Germain travel to second-tier Brest, Monaco visit Vannes and Lille face a trip to Amiens.
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