Naismith was withdrawn in the 89th minute of Saturday's 2-1 Premier League home win over West Ham.
And while the hamstring complaint is not considered serious, Roberto Matinez is not expecting to have the Scotland forward available for the trip to Germany,
The Spanish boss said: "It was really late in the game, it was probably a little fatigue in the muscle.
"He overstretched his hamstring but we're going to assess it; it looks like he's picked up a soft tissue injury.
"He will probably he will miss Thursday, but don't expect him to be out for too long.”
'People will remember us because we got to No.1 in the world rankings and achieved great things - but our biggest regret is that we didn’t win anything': Ex-Everton star Kevin Mirallas opens up on 'honour' of being part of nation's golden generation
‘I’m sure we’d have finished in the top four or five if he hadn’t joined Chelsea in January. Him leaving damaged the team, but we couldn’t stand in his way’: Alan Curbishley reflects on failed Champions League dream after selling key player
