Monaco midfielder Joao Moutinho will miss up to six weeks with an ankle injury suffered in his side's draw against Lille.
The Portugal international was substituted just after the hour-mark of Monaco's 0-0 Ligue 1 draw at home to Lille on Friday.
The club confirmed the severity of the injury on Sunday, saying Moutinho would miss between four and six weeks.
Moutinho's injury is a blow to Monaco's chances of reaching the UEFA Champions League group stages.
The 28-year-old is certain to miss his team's play-off against Valencia, who host the first leg on Wednesday.
Monaco are also set to be without Moutinho for their clash against Ligue 1 leaders Paris Saint-Germain on August 30.
'I love my job. I love being able to play this sport. In the end, there’s something addictive in winning for me' Alexia Putellas speaks about what drove her back from an ACL injury to lift the World Cup
Alexia Putellas: "We’re already the only club to have won the men’s and women’s Champions League, so the only thing even more historic to do than that would be to win it in the same season"
