Leaders Girondins Bordeaux will not play as the French League agreed to postpone their game against Auxerre to give them some rest before their Champions League last-16 first leg at Olympiakos on Tuesday.
Second-placed Montpellier have defence worries before they visit St Etienne on Saturday although they have not conceded a goal in their last five league games.
Bosnian Emir Spahic has missed three days of training because of a sore leg and fellow centre back Nenad Dzodic is out through a groin injury.
Right-back Garry Bocaly fractured his right hand this week and will be replaced by veteran Cyril Jeunechamp.
Lille striker Tulio De Melo is out for up to six weeks after injuring his right knee during a training session on Wednesday. Third-placed Lille visit Stade Rennes on Sunday.
Olympique Marseille coach Didier Deschamps said he could reshuffle his team for their game at Nancy on Sunday three days after their 3-1 Europa League win at Copenhagen.
"The game that follows a Europa League tie is always difficult. Every player will be involved in the next couple of weeks but what worries me now is our next game at Nancy," Deschamps told reporters.
Monaco will have to make do without defender Sebastien Puygrenier and midfielder Alejandro Alonso, who are both suspended, when they play at Lens on Saturday.
Nice's board warned coach Didier Olle-Nicolle he could be sacked if his players don't beat Lorient on Saturday.
"He will still be there against Lorient, that's for sure, but that's his last chance. We must win against Lorient," chief executive Patrick Governatori was quoted as saying by L'Equipe this week.
Nice one place above the relegation zone after 11 league games without a win.
Paris Saint-Germain will miss suspended Benin playmaker Stephane Sessegnon when they host Toulouse on Saturday after he was sent off in their 1-0 French Cup win against fourth division Vesoul earlier this month.
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