Olympique Marseille will be without forward Bakary Kone and midfielders Benoit Cheyrou (pictured) and Fabrice Abriel when they host Olympique Lyon on Sunday after the three picked up injuries in their team's 2-1 home defeat to Benfica in the Europa League on Thursday.
Abriel is suffering from a groin injury and will be out for two weeks while Kone picked up a thigh injury and will be sidelined for 10 days.
Cheyrou will undergo checks on Friday to assess the extent of his injury, the nature of which has not been specified by the Marseille medical staff.
Defeat at Olympique Marseille would not bury Olympique Lyon's chances of winning an eighth Ligue 1 title, said Sweden midfielder Kim Kallstrom.
"Even if there is a lot at stake, I do not think it will be over for us if we lose," Kallstrom told Lyon's website.
"Victory would be good for our confidence and it would put a lot of pressure on our rivals."
Lyon are fifth in the standings with 51 points from 28 matches, two points behind leaders Girondins Bordeaux. Marseille are in sixth position one point adrift but with a game in hand.
Third-placed AJ Auxerre will have to make do without defenders Jean-Pascal Mignot, Jeremy Berthod and Kevin Malaga, who are all suspended when the Burgundy side host Le Mans on Saturday.
St Etienne will be without Christophe Landrin when they host Nancy on Saturday after their key midfielder picked up a groin injury during training, L'Equipe reported on Friday.
Striker Peguy Luyindula is a doubt for Paris Saint-Germain's trip to Nice on Saturday with knee pain.
The game will be played behind closed doors after the French league took disciplinary action against Nice following a pitch invasion by some of their fans at Monaco earlier this season.
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