Saturday's games between Burnley and Stoke City, Fulham and Portsmouth and Sunderland and Bolton Wanderers have been called off, as has Sunday's match between Liverpool and Tottenham Hotspur.
Champions Manchester United visit Birmingham City, who are unbeaten in 12 matches, on Saturday again without injured defenders Rio Ferdinand, John O'Shea and Nemanja Vidic.
Vidic is out for up to 10 days with a nerve problem in his right leg while goalkeeper Edwin van der Sar is still on compassionate leave because of his wife's illness.
"We sent (Vidic) to a specialist to get the problem diagnosed and we know what exercises he needs to do now. It's not a long-term issue and we can control it," manager Alex Ferguson told the club's website.
City, who have not lost at home since September, are without experienced midfielder Lee Carsley (ankle injury) and defender Stuart Parnaby (back).
Arsenal hope to have Tomas Rosicky back for Saturday's home match with Everton after the Czech midfielder shrugged off a groin injury.
Captain Cesc Fabregas (hamstring), striker Nicklas Bendtner (groin) and defender Gael Clichy (back) all remain sidelined.
Everton manager David Moyes could give forward Landon Donovan his debut after the U.S. international joined on loan from Los Angeles Galaxy.
Second-from-bottom Hull City are boosted by the return to fitness of defender Paul McShane for Saturday's home match with leaders Chelsea.
Chelsea forward Daniel Sturridge could start alongside the fit-again Nicolas Anelka with Didier Drogba and Salomon Kalou on African Nations Cup duty.
Aston Villa's in-form winger James Milner looks set to return from a foot injury for Saturday's clash at Wigan Athletic.
Wigan manager Roberto Martinez is waiting on the fitness of midfielder Mohamed Diame.
West Ham United are hoping midfielders Mark Noble and Scott Parker will be fit for Sunday's visit of Wolverhampton Wanderers. Guillermo Franco and Jonathan Spector are also expected to be in the squad.
