Alexis Sanchez joined Romelu Lukaku on the sidelines for Manchester United's clash with Brighton and Hove Albion, while Marcus Rashford was handed a start up front.
United manager Jose Mourinho had already confirmed Lukaku's absence through injury after the Belgium international hobbled out of Sunday's Premier League victory over Arsenal.
But reports emerged on Friday that Sanchez had also not travelled to Brighton and confirmation arrived with the news that Rashford – often deployed out wide – had been handed a central striking role.
Mourinho made six changes in all, with Matteo Darmian, Marcus Rojo, Juan Mata, Anthony Martial and last week's match-winner Marouane Fellaini joining Rashford in the side.
Antonio Valencia missed out on the squad, while Victor Lindelof, Ander Herrera and Jesse Lingard dropped to the bench.
Here we go!changes to the starting XI from 's victory over Arsenal... May 4, 2018
Brighton made two changes to the side that drew at Burnley last time out, with Davy Propper and Glenn Murray back in the side at the expense of Beram Kayal and Leonardo Ulloa.
‘Milan didn’t collapse against Liverpool in Istanbul. We lost focus for six minutes – for the other 114, we played an extraordinary, beautiful game’: AC legend claims they were 'extraordinary' against Reds in 2005 Champions League final
‘Charlton could have qualified for Europe, but selling Scott Parker to Chelsea made the difference. The manager didn’t want him to go and there was a disagreement’: Former Addicks star highlights key reason why they failed to maintain 2003/04 form
