Dairon Mosquera emerged as the unlikely hero on Wednesday, with his injury-time goal lifting Santa Fe past Internacional 1-0.
The quarter-final first-leg fixture was petering out for a draw at the Estadio Nemesio Camacho until Mosquera headed home powerfully from Omar Perez's corner in the 92nd minute in Bogota, Colombia.
Mosquera, who had not scored for Santa Fe this season, found himself unmarked inside the penalty area as he headed low past Internacional goalkeeper Alisson in the second minute of additional time.
Santa Fe, who have won their past three home matches in the Copa Libertadores, will travel to Porto Alegre for the return leg on May 27.
‘He instantly popped into our ratings as one of the best U21 midfielders in Europe. The impressive thing is Slot has made him into more of a no.6' Inside Ryan Gravenberch's transformation at Liverpool
‘I don’t think Liverpool would look at Ollie Watkins, a striker isn’t a pressing issue for them – it’s Arsenal who need one’ Former Reds star explains why his old club don’t need an out-and-out forward this summer
