Milan won 2-1 at Siena on Saturday in their Serie A opener with the impressive Ronaldinho playing behind frontmen Alexandre Pato and Marco Borriello.
However, Berlusconi wants to see Ronaldinho pushed further forward for Saturday's meeting with champions Inter Milan, who were held 1-1 at home by Bari on Sunday.
"If I was choosing the formation, I would play Clarence Seedorf in the hole, Pato as the main striker with Ronaldinho as second striker," the Italian prime minister told 7 Gold television late on Monday.
New striker Klaas Jan Huntelaar is available for the derby after serving a ban against Siena carried over from his time at Real Madrid.
Inter are close to a deal for Real playmaker Wesley Sneijder, media reports have said, with the Dutchman possibly starting the derby after coach Jose Mourinho questioned Sulley Muntari's fitness given the Ghanaian's commitment to Ramadan.
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