The Premier League's bottom two sides meet at the Cardiff City Stadium this weekend, having won just 11 top-flight matches between them this season.
Defeat would represent a hammer blow for the survival hopes of both clubs and Solskjaer, who was appointed Cardiff manager in January, insists his players can afford nothing less than a win.
"It's a big game. It's the first of the last 10 and a great chance to kick start the final run in," said the Norwegian.
"We'll go out and attack it in that way on Saturday. We've prepared well and I've got a clear view on the task we face.
"It's one where neither team want a draw, both need the win.
"We've got the home advantage and support, which will be important."
Fulham have won just once in the league in 2014 - a 2-1 victory over West Ham on New Year's Day.
"Felix (Magath) has had a long career in the game and lots of success as a manager," he added.
"He'll have them organised and ready for it."
