Spain moved to the top of UEFA Nations League group A2 following a 2-0 win at home to Czech Republic on Sunday.
Valencia's Carlos Soler and Paris Saint-Germain's Pablo Sarabia (who spent last season on loan with Sporting CP in Portugal) scored a goal in each half to give Luis Enrique's side a comfortable win at Malaga's La Rosaleda stadium.
La Roja had rescued a point thanks to a 90th-minute leveller in a 2-2 draw between the two teams in Prague last weekend and remain unbeaten in their four fixtures with two wins and two draws so far.
Tonight's win sees Spain move above Portugal in top spot after the 2016 European champions lost 1-0 away to Switzerland in Geneva.
Portugal were without star man Cristiano Ronaldo, with the Manchester United attacker rested by coach Fernando Santos and he was missed in a disappointing defeat.
Spain top the sector with eight points, one ahead of Portugal. Czech Republic are third with four points and Switzerland are off the mark after tonight's win, but still in fourth with three.
