Twente Enschede beat NEC Nijmegen 2-1 and Ajax Amsterdam overcame 10-men Utrecht 4-0.
PSV remain top with 65 points after 25 matches, one ahead of Twente. Ajax are third on 58.
Balazs Dzsudzsak (pictured) converted a sixth -minute penalty to put PSV ahead before Ibrahim Afellay, Danny Koevermans and Nordin Amrabat effectively settled the match.
Charlison Benschop pulled one back for the visitors in the second half but Koevermans completed the rout with his second.
Luuk de Jong struck from close range to put Twente ahead but midway through the second half Bjorn Vleminckx equalised.
Costa Rican Bryan Ruiz earned Steve McClaren's men the three points with his 17th of the season five minutes before time.
Fourth-placed Feyenoord, on 47 points, won 3-2 at Groningen with central defender Ron Vlaar scoring the winner in injury time with a long drive.
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