Manchester United manager Louis van Gaal has ruled Antonio Valencia out of the club's Capital One Cup match at home to Middlesbrough on Wednesday.
The Ecuador international limped off with a foot injury in the derby stalemate against Manchester City on Sunday.
Valencia suffered the injury mid-way through the first half but continued to play until he was replaced by Matteo Darmian in the final ten minutes.
Van Gaal confirmed the 30-year-old will miss United's fourth-round encounter against Championship opposition and conceded there are a lot of players in the injury "red zone".
"Of course, Valencia is injured - that we could all see," Van Gaal told MUTV.
"But I have a lot of players in the 'red zone' because we have had a lot of matches and we have a lot of matches to play. I have to see if I can use them or not.
"I have to decide tomorrow [Wednesday]. We need all the days to recover at this moment, so it is difficult to say."
