Ferguson, who had 10 senior players out of action as United chase trophies in four competitions, said forward Danny Welbeck and left back Fabio da Silva were likely to be out of the squad for Tuesday's Premier League game at West Bromwich Albion.
Welbeck limped out of the 2-1 win over Spurs late in the second half at Old Trafford to be replaced by new signing Serbian Zoran Tosic, while Brazilian Fabio's debut for the club ended when he was injured early in the second half.
"Danny Welbeck got kicked on the ankle. It's nothing serious but I don't think he'll make Tuesday," United manager Alex Ferguson told MUTV, the club's official TV channel.
"Young Fabio has a calf strain and it's disappointing because he's only just come back from a long injury. He did very well too.
"You could do without these things but I've got (Darren) Fletcher, (Ryan) Giggs, (Darron) Gibson and (Rodrigo) Possebon who are all fresh. I'm okay with midfield players and the front players. It's just the fullback positions that cause us a bit of concern."
Ferguson said on Friday he had 10 players out of contention to face Spurs and although Cristiano Ronaldo, who was doubtful on Saturday morning, did start the match he came off in the 71st minute.
"We had to get the doctor in to see Cristiano," said the United manager.
"He had a bit of a bug and I think it showed today, I don't think he was anywhere near ready. But he showed the appetite to play and it's always good to have him on the pitch, opponents are always aware of him. He should be better by Tuesday."
