Lauren Hemp is not in the matchday squad for the Lionesses as they take on Belgium in the Nations League on Friday evening.
England are looking to compound their impressive 1-0 win against world champions Spain in February.
The games are also useful preparation for the European Championships which kick off on 2 July.
Lauren Hemp: Why isn't she playing?
Hemp, who has been a key star for the team over the last few years and won the Euros with England in 2022, has not played a game since Manchester City defeated Tottenham 4-0 on 8 November.
She sustained a knee injury and club City have not put a timeline on her recovery.
The injury is a blow for the Lionesses with Hemp in sparkling form this season but they have managed to come away with some results without her.
They beat Spain and drew 1-1 with Portugal in February and towards the end of 2024 they drew 0-0 against the USA and beat Switzerland 1-0.
England are about to have a double header against Belgium, with the two teams playing each other once again on Tuesday.
The Lionesses are then scheduled Portugal and Spain in May and June respectively. It is not currently clear if Hemp will be available for those games.
City did say Hemp has returned to training in March but for the foreseeable the national team are without the star.
She is not the only long term injury England are dealing with. Alex Greenwood and Georgia Stanway are also not available.
Stanway suffered a lateral collateral ligament tear in her right knee which has made her chances of being in the Euros squad diminish.
While, Greenwood sustained an MCL tear and is just getting back onto grass in training.
